منابع مشابه
Novel Vaccine Adjuvants
Vaccines still remain the most successful method for protection and eradication against diseases. However, to avoid harmful effects associated with whole organism vaccines, new vaccine candidates are composed of parts of an organism, and therefore these are weakly immunogenic. Adjuvants are essential components of vaccines that nonspecifically stimulate the immune system, particularly the innat...
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Boosting is a kind of ensemble methods which produce a strong learner that is capable of making very accurate predictions by combining rough and moderately inaccurate learners (which are called as base learners or weak learners). In particular, Boosting sequentially trains a series of base learners by using a base learning algorithm, where the training examples wrongly predicted by a base learn...
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A procedure for detecting outliers in regression problems is proposed. It is based on information provided by boosting regression trees. The key idea is to select the most frequently resampled observation along the boosting iterations and reiterate after removing it. The selection criterion is based on Tchebychev’s inequality applied to the maximum over the boosting iterations of ...
متن کاملInnate immunity and adjuvants
Innate immunity was for a long time considered to be non-specific because the major function of this system is to digest pathogens and present antigens to the cells involved in acquired immunity. However, recent studies have shown that innate immunity is not non-specific, but is instead sufficiently specific to discriminate self from pathogens through evolutionarily conserved receptors, designa...
متن کاملNovel Adjuvants for Vaccines
The review covers basic recent discoveries on the mechanism of action of adjuvants, which have been developed in the last decade. In particular, it focuses on the activation of TOLL like receptors and subsequent release of pro-inflammatory lymphokines (innate immunity), which, in turn, are thought to activate antigen specific responses (adaptive immunity). Given the number of novel adjuvants av...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2014
ISSN: 1945-3477
DOI: 10.1038/scibx.2014.1281